Polynucleotides are biological molecules that exist in our body. In aesthetic medicine, there are polynucleotide formulations used for regenerative purposes, usually extracted from salmon sperm or other fish. When used in aesthetic treatments, they act as "activators" of cells and enhance collagen production, improve skin hydration and elasticity, while accelerating regeneration processes. They can be used as an ingredient in mesotherapy , and by injecting them into the deeper layers of the epidermis, the appropriate environment is created that helps the skin function better, renew itself naturally, and look more fresh and youthful .
Polynucleotides act at a cellular level, activating fibroblasts and stimulating the production of collagen and elastin. At the same time, they bind to adenosine receptors (A2A), reducing oxidative stress and inflammation. In this way, they support tissue regeneration and restoration of skin health.
Benefits of polynucleotide treatment
Improved hydration
Thanks to their ability to retain large amounts of water, polynucleotides enhance skin hydration.
Increased elasticity & firmness
Increased collagen strengthens the skin, reduces sagging and makes it firmer.
Radiance & even tone
The skin gains a radiant appearance, as it helps to smooth out minor imperfections, providing a more refreshed, youthful look.
Quick return to daily life
The treatment process may result in mild swelling or redness which subsides within a few hours, allowing you to quickly return to your activities.
Continuous cell renewal
The action of polynucleotides does not stop after treatment. The body continues to renew cells and enhance the natural mechanisms of the skin, maintaining the results for longer.
Preventive anti-aging
Polynucleotides are not only for correcting existing signs, but also for prevention. By enhancing the skin's natural mechanisms, they delay the appearance of wrinkles and sagging, thus offering an ideal solution for those who wish to prevent the signs of aging.
Depending on your needs, the specialist doctor will suggest the appropriate treatment plan, which may include one or more sessions at specific intervals.
Dr. Dimitroulas Nikolaos
The session begins with the preparation of the area where the application will take place. Initially, a gentle cleansing is performed, and anesthetic cream is applied to ensure your comfort. Next, the doctor carefully proceeds with the injection of polynucleotides at the treatment points, following the natural lines of your face. During the procedure, you may feel a slight pressure or discomfort, and the process is brief. Once completed, a special cream is applied to soothe the skin and further support its natural regeneration.
Usually, after the session, you can immediately return to your daily activities. You may experience mild redness or slight swelling, but these symptoms subside quickly. After the first few weeks, you will gradually notice an improvement in the texture, elasticity, and radiance of your skin. These results will enhance over time as the polynucleotides work within your body. For the best possible outcome, you can maintain a proper skincare routine. Use sunscreen daily and keep your skin well-hydrated. Additionally, using specialized cosmetics can further boost and prolong the benefits of the treatment.
Combination Therapies
Polynucleotides can also be combined with other treatments for even more comprehensive results:
RF (radiofrequencies)
for greater tightening and elasticity enhancement.
Fractional laser
for improving scars and texture, with polynucleotides accelerating healing
PRP
the regenerative action is synergistically enhanced, offering more intensive results
If you are interested in a combination, the doctor will suggest a personalized protocol that combines treatments based on your skin's needs.
Polynucleotides: Side Effects
- Mild redness that subsides within 6-24 hours
- Slight swelling for 1-2 days
- Bruising at injection sites that disappears within 2 weeks
- Mild itching as regeneration occurs
- Allergic reactions (extremely rare due to high purity)
- Infection (only if care instructions are not followed)
- Formation of small nodules (very rare)
Polynucleotide (PN/PDRN) treatment is generally considered safe and well-tolerated. Reactions are usually mild and temporary, and what you might see after the session is some minor redness, slight swelling, or small bruises at the application site, which subside quickly. Application is not recommended during pregnancy or breastfeeding, as there is insufficient data for these cases. If you have a history of severe fish allergy, it is important to inform your doctor, as some formulations are derived from fish DNA. Also, treatment should ideally be avoided if there is an active infection or inflammation in the area. The doctor will individually evaluate your case and determine the most suitable protocol for you.
Polynucleotide treatment is a modern approach based on the body's natural ability to regenerate and nourish the skin. It provides deep hydration, boosts collagen, and generally improves skin quality. Book your appointment at Facemed Clinic and achieve a firm and radiant look.
Cost
Who is polynucleotide treatment for?
This treatment is mainly suitable for individuals who wish to improve their skin's texture and elasticity, combating mild signs of aging and dullness. It is suitable for men and women, unless there are specific dermatological or other medical contraindications. You can view our detailed guide on choosing the best mesotherapy based on your needs.
How long do the results last?
Improvements in skin appearance become gradually visible as the polynucleotides work and the body continues to produce new collagen. Their duration depends on factors such as your lifestyle, daily skincare routine, and general health status. With proper care, you can enjoy the benefits for several months.
How many sessions will I need?
The number of sessions depends on your skin's condition and your goals. Often, 2-4 initial sessions every 2-4 weeks are enough for a visible result, followed by maintenance every 6-12 months. However, in cases of more advanced skin laxity or dullness, more sessions or a combination of treatments may be required.
What is the price of polynucleotide treatment?
Polynucleotide treatment costs 400€.
